msi slotMost M.2 PCIe SSD slots (including combo M.2 slots) support the NVMe protocol but none of the M.2 SATA-only SSD slots support it. NVMe is optional. You can use anSlot: 2x PCI-E x16 slot 1x PCI-E x1 slot PCI_E1 Gen PCIe 5.0 supports up to x16 (From CPU) ... MSI trademarks and copyrhted materials may be used only with written permission from